Expert Exchange

Vishva Dixit Shares Insights on His Early Influences, Research Career, Key Findings, and What it Takes to Be Successful in Science

In this interview, Vishva Dixit, MD, talks with Neil S. Greenspan, MD, PhD, senior editor of Pathogens and Immunity aboutwhat his career in science has revealed about biology in humans, but also what it has revealed about how to be successful in science. Dr. Dixit is a world-famous immunologist and biochemist who has made major contributions to the study of innate immunity in general and particularly to understanding inflammasome activation. He is vice president and senior fellow in physiological chemistry at Genentech

>>Read the Transcript.

>>Watch the Interview.


Raymond Schinazi Discusses the Discovery of Early Antiretroviral Agents and Sofosbuvir

Dr. Raymond Schinazi talks about his career with Dr. Michael Lederman and Dr. Neil Greenspan, senior editors of Pathogens and Immunity. Dr. Schinazi has invented numerous powerful antiviral agents including the antiretrovirals lamivudine (3TC) and emtricitabline (FTC) and the anti-hepatitis C agent sofosbuvir. These agents have saved millions of lives, and here, Dr. Schinazi talks in detail about how these agents were invented, how they work, how they are being applied and offers his thoughts about newer approaches to treat viral infections.

>>Read the Transcript.

>>Watch the Interview.


Julie Segre, PHD: The Link Between Math and Biology, and the Importance of Collaboration

In this interview with Pathogens and Immunity (PAI), Dr. Julie Segre, researcher for the National Human Genome Research Institute and expert in the field of skin biology, discusses the influences that formed her scientific career and the link between her background in mathematics and molecular biology.

She shares her experience developing the human genome project and how she evolved into studies focused on the microbiome and its impact on health and skin disease with PAI’s senior editors, Mahmoud Ghannoum, PHD, and Robert A. Bonomo, MD.

She says she enjoys transitioning into new areas of research and pairing her expertise with the expertise of colleagues to ask new questions. “I am comfortable being uncomfortable,” she says. As part of being a “good scientific citizen,” she says thinking about the translational aspect of how research will advance care is an important consideration when devising a study. “Don’t just think someone else will pick this up and try to communicate the findings,” she says, adding that she finds herself focusing now on collaboration, how to build and maintain scientific community, as well as how to communicate ideas. “I do believe that the community is stronger than each of us as individuals,” she says.

She will present “Tracking an Emerging Pathogen Candida auris in Nursing Homes with Genomic-Epidemiology” at the upcoming Keystone Symposia: The Human Microbiome: Ecology and Evolution, taking place December 4-7 in Fairmont Banff Springs, Alberta, Canada.

*Video produced as a collaboration between Pathogens and Immunity and Keystone Symposia. 

Erica Ollmann Saphire: How the Study of HIV and Other Viruses Informed the Rapid Development of Vaccines and Therapeutic Antibodies Against COVID-19

In this interview, Dr. Erica Ollmann Saphire discusses how structural biology informs antibody drug development against COVID-19, in a sneak preview of her Keynote Address at the Keystone Symposia on “Antibodies as Drugs,” which takes place April 27-30, 2022.

>> In this second part, Dr. Ollmann Saphire shares how her work on hemorrhagic fevers prepared her, and the world, for a rapid response to COVID-19.

>>Read the Transcript.

*Video produced as a collaboration between Pathogens and Immunity and Keystone Symposia. 

PAI Senior Editors Neil Greenspan, MD, PhD, and Michael Lederman, MD, Talk With David Baltimore, PhD

David Baltimore, PhD, reflects on his contributions to biomedical science, which have had a major influence on the fields of molecular biology, virology, cancer, and immunology.

>>20-Minute Video plus Transcript.



PAI Senior Editors Robert Bonomo, MD, and Michael Lederman, MD, Talk With Arturo Casadevall, MD, PhD

Dr. Arturo Casadevall shares insight into his childhood, what motivated him to go into biomedical research, the impact of the AIDS epidemic, and the lessons learned that he imparts to younger scientists.

>>20 Minute Video plus Transcript.




Peter Doherty, Nobel Laureate: Questions and Reflections Concerning MHC Restriction and other Fruits of a Life of Biomedical Erudition

Peter Doherty, PhD, talked with PAI Senior Editor Neil Greenspan, MD, PhD, about the landmark article he and Rolf Zinkernagel published in Nature that described the ability of lymphocytic choriomeningitis virus (LCMV)-specific cytotoxic T cells to lyse LCMV-infected, 51Cr-labeled target cells if the target cells shared class I major histocompatibility complex (MHC) molecules with these T cells.

>>Q&A Article.



Current Issue Articles | Volume 8, Issue 1

Carbon Dioxide Monitoring Demonstrates Variations in the Quality of Ventilation on Public Transportation Buses and University Student Shuttle Vans and Identifies Effective Interventions
Published: November 21, 2023 | 10.20411/pai.v8i1.619

Vishva Dixit Shares Insights on His Early Influences, Research Career, Key Findings, and What it Takes to Be Successful in Science
Published: November 20, 2023 | 10.20411/pai.v8i1.643

Dynamics of T-cell Responses Following COVID-19 mRNA Vaccination and Breakthrough Infection in Older Adults
Published: November 17, 2023 | 10.20411/pai.v8i1.613

Raymond Schinazi Discusses the Discovery of Early Antiretroviral Agents and Sofosbuvir
Published: November 6, 2023 | 10.20411/pai.v8i1.624

The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review
Published: October 18, 2023 | 10.20411/pai.v8i1.597

Genomic Characterization of 2 Cutibacterium acnes Isolates from a Surgical Site Infection Reveals Large Genomic Inversion
Published: October 5, 2023 | 10.20411/pai.v8i1.606

Military Medicine and Medical Research as a Source of Inspiration and Innovation to Solve National Security and Health Challenges in the 21st Century
Published: September 8, 2023 | 10.20411/pai.v8i1.596

Immunohematologic Biomarkers in COVID-19: Insights into Pathogenesis, Prognosis, and Prevention
Published: June 26, 2023 | 10.20411/pai.v8i1.572

A Community-Driven Framework to Prioritize the Use of Donated Human Biological Materials in the Context of HIV Cure-Related Research at the End of Life
Published: May 24, 2023 | 10.20411/pai.v8i1.583

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