Expert Exchange

Julie Segre, PHD: The link between math and biology, and the importance of collaboration

In this interview with Pathogens and Immunity (PAI), Dr. Julie Segre, researcher for the National Human Genome Research Institute and expert in the field of skin biology, discusses the influences that formed her scientific career and the link between her background in mathematics and molecular biology.

She shares her experience developing the human genome project and how she evolved into studies focused on the microbiome and its impact on health and skin disease with PAI’s senior editors, Mahmoud Ghannoum, PHD, and Robert A. Bonomo, MD.

She says she enjoys transitioning into new areas of research and pairing her expertise with the expertise of colleagues to ask new questions. “I am comfortable being uncomfortable,” she says. As part of being a “good scientific citizen,” she says thinking about the translational aspect of how research will advance care is an important consideration when devising a study. “Don’t just think someone else will pick this up and try to communicate the findings,” she says, adding that she finds herself focusing now on collaboration, how to build and maintain scientific community, as well as how to communicate ideas. “I do believe that the community is stronger than each of us as individuals,” she says.

She will present “Tracking an Emerging Pathogen Candida auris in Nursing Homes with Genomic-Epidemiology” at the upcoming Keystone Symposia: The Human Microbiome: Ecology and Evolution, taking place December 4-7 in Fairmont Banff Springs, Alberta, Canada.

*Video produced as a collaboration between Pathogens and Immunity and Keystone Symposia. 

Erica Ollmann Saphire: How the Study of HIV and Other Viruses Informed the Rapid Development of Vaccines and Therapeutic Antibodies Against COVID-19

In this interview, Dr. Erica Ollmann Saphire discusses how structural biology informs antibody drug development against COVID-19, in a sneak preview of her Keynote Address at the Keystone Symposia on “Antibodies as Drugs,” which takes place April 27-30, 2022.

>> In this second part, Dr. Ollmann Saphire shares how her work on hemorrhagic fevers prepared her, and the world, for a rapid response to COVID-19.

>>Read the Transcript.

*Video produced as a collaboration between Pathogens and Immunity and Keystone Symposia. 

PAI Senior Editors Neil Greenspan, MD, PhD, and Michael Lederman, MD, Talk With David Baltimore, PhD

David Baltimore, PhD, reflects on his contributions to biomedical science, which have had a major influence on the fields of molecular biology, virology, cancer, and immunology.

>>20-Minute Video plus Transcript.



PAI Senior Editors Robert Bonomo, MD, and Michael Lederman, MD, Talk With Arturo Casadevall, MD, PhD

Dr. Arturo Casadevall shares insight into his childhood, what motivated him to go into biomedical research, the impact of the AIDS epidemic, and the lessons learned that he imparts to younger scientists.

>>20 Minute Video plus Transcript.




Peter Doherty, Nobel Laureate: Questions and Reflections Concerning MHC Restriction and other Fruits of a Life of Biomedical Erudition

Peter Doherty, PhD, talked with PAI Senior Editor Neil Greenspan, MD, PhD, about the landmark article he and Rolf Zinkernagel published in Nature that described the ability of lymphocytic choriomeningitis virus (LCMV)-specific cytotoxic T cells to lyse LCMV-infected, 51Cr-labeled target cells if the target cells shared class I major histocompatibility complex (MHC) molecules with these T cells.

>>Q&A Article.




Current Issue Articles

Immune Dysregulation in Acute SARS-CoV-2 Infection
Published: February 20, 2023 | 10.20411/pai.v7i2.537

Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection
Published: February 17, 2023 | 10.20411/pai.v7i2.560

HIV-1 is Transported into the Central Nervous System by Trafficking Infected Cells
Published: January 23, 2023 | 10.20411/pai.v7i2.524

Evaluation of Interventions to Improve Ventilation in Households to Reduce Risk for Transmission of Severe Acute Respiratory Syndrome Coronavirus 2
Published: December 10, 2022 | 10.20411/pai.v7i2.553

B-Cell Responses to Sars-Cov-2 mRNA Vaccines
Published: December 9, 2022 | 10.20411/pai.v7i2.550

Real-World Evidence on the Effectiveness of Plexiglass Barriers in Reducing Aerosol Exposure
Published: November 4, 2022 | 10.20411/pai.v7i2.533

Pandemics and the English Language: Concepts Critical for Conversing About COVID-19
Published: November 10, 2022 | 10.20411/pai.v7i2.542

Update on the Pathogenesis, Virulence, and Treatment of Candida auris
Published: October 21, 2022 | 10.20411/pai.v7i2.535

Therapeutic Bacteriophages for Gram-Negative Bacterial Infections in Animals and Humans
Published: October 17, 2022 | 10.20411/pai.v7i2.516

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