Raymond Schinazi Discusses the Discovery of Early Antiretroviral Agents and Sofosbuvir

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Michael M. Lederman
Neil S. Greenspan


In this interview, Raymond Schinazi, PhD, Hon DSc, talks about his career with Michael M. Lederman, MD, and Neil S. Greenspan, MD, PhD, senior editors of Pathogens and Immunity. Dr. Schinazi has invented numerous powerful antiviral agents including the antiretrovirals lamivudine (3TC) and emtricitabine (FTC) and was instrumental in the discovery of the anti-hepatitis C agent sofosbuvir. These drugs have saved millions of lives and, here, Dr. Schinazi shares in detail how these agents were invented, how they work, and how they are being applied. He also offers his thoughts about newer approaches to treat viral infections.


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Author Biography

Michael M. Lederman, Case Western Reserve University, Cleveland, Ohio

Dr. Lederman has served as intern, resident, chief resident in Medicine and fellow in Infectious Diseases at Case Western Reserve University where he joined the faculty in 1980. He is a member of the American Association of Immunologists, and is a Fellow of the Infectious Diseases Society of America, the American Association for the Advancement of Science and the American Academy of Microbiology.


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