Ten Years HIV Free: An Interview with “The Berlin Patient,” Timothy Ray Brown

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Michael M. Lederman
Earl Pike

Abstract

It was just about 10 years ago that Timothy Ray Brown was cured of HIV infection by receiving bone marrow stem cell transplantations from an HLA matched donor who also was homozygous for the CCR5 delta 32 mutation that renders immune cells resistant to infection by most HIV viruses. During an October 2017 visit to Cleveland to help launch a number of clinical trials targeting the Cure, Timothy sat down with Pathogens and Immunity editor Michael Lederman and community activist Earl Pike to talk about his experiences.

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Author Biography

Michael M. Lederman, Case Western Reserve University; Associate Director, Center for AIDS Research, UH Cleveland Medical Center

Dr. Lederman has served as intern, resident, chief resident in Medicine and fellow in Infectious Diseases at Case Western Reserve University where he joined the faculty in 1980. He is a member of the American Association of Immunologists, the Infectious Diseases Society of America, the HIV Medicine Association and is a councilor of the Clinical Immunology Society. He is on the editorial boards of AIDS, the Journal of AIDS and Clinical Immunology.

References

1. Hutter G, Nowak D, Mossner M, Ganepola S, Mussig A, Allers K, Schneider T, Hofmann J, Kucherer C, Blau O, Blau IW, Hofmann WK, Thiel E. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692-8. PubMed PMID: 19213682. doi: 10.1056/NEJMoa0802905

2. Lederman MM, Cannon PM, Currier JS, June CH, Kiem H-P, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? Pathogens and Immunity. 2016;1(1):154-64. doi: 10.20411/pai.v1i1.133

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