%PDF-1.4
%
1 0 obj
<>>>
endobj
2 0 obj
<>stream
application/pdf
Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Isolated From the Blood and Urine of Patients with Hematologic Malignancies and Stem Cell Transplant Recipients
Fluoroquinolone resistance
Escherichia coli
stem cell transplant
hematologic malignancy
Copyright 2016
Fluoroquinolone (FQ) antibiotics have been shown to reduce mortality and the number of febrile episodes when used as prophylaxis during neutropenia. Prior studies suggest that prophylaxis may result in increasing rates of FQ resistance. Fluoroquinolone non-susceptibility trends in Escherichia coli isolated from blood and urine cultures were evaluated over a 16-year period during which prophylaxis was initiated in patients with hematologic malignancies and stem cell transplants. Non-susceptibility rates increased after the introduction of prophylaxis, with yearly non-susceptibility rates rising from 30%¬–33% to 40%–88% in blood isolates. The high rates of non-susceptibility now observed raise concerns about the continued efficacy of FQ prophylaxis. This concern exists particularly in those patients undergoing stem cell transplants where the total FQ non-susceptibility rates over the study period were 82.3%. Further evaluation of the effect of FQ prophylaxis on antibiotic resistance and its efficacy in the setting of increased rates of resistance is warranted.
Christopher G. Hauck
Pearlie P. Chong
Melissa B. Miller
Katarzyna Jamieson
Jason P. Fine
Matthew C. Foster
Thomas C. Shea
David van Duin
2018-10-03T06:56:06-04:00
2018-10-03T06:56:08-04:00
2018-10-03T06:56:08-04:00
Adobe InDesign CC 13.0 (Windows)
uuid:7fbce2ba-56d2-4492-91df-e67b0a0f3e1a
xmp.did:c2c10248-8d97-b244-b908-362d8aaa04cc
xmp.id:b5b6930a-9a80-7f4c-8982-b58fdec06e3c
proof:pdf
xmp.iid:660ea87a-95d4-be45-9bd6-56f9f133a995
xmp.did:660ea87a-95d4-be45-9bd6-56f9f133a995
xmp.did:c2c10248-8d97-b244-b908-362d8aaa04cc
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CC 13.0 (Windows)
/
2018-10-03T06:56:07-04:00
True
https://paijournal.com/index.php/paijournal/article/view/115/64
Adobe PDF Library 15.0
False
endstream
endobj
5 0 obj
<>
endobj
6 0 obj
<>
endobj
7 0 obj
<>
endobj
3 0 obj
<>
endobj
12 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
13 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
14 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
15 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
16 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
17 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
18 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
19 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
20 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>>
endobj
51 0 obj
[53 0 R]
endobj
52 0 obj
<>stream
HWSH_1+K譐J@..u\][!J v _f46*LOOw`:TwP.gP,~vZ}%FӁoC%Y0Vq~az?Zb<&^_^zs?XHTa%7BGj92##8PAg|`DBNGl}RG^jY3V7`_}jwO;^^r
;7o'V1{Z[Oyrػӧ
ʇ TޟnԑaK_4%e_<^UaɁ/
o'國%x-*sgCCH9bXڋqnj~~95h8<
lIi[46w!uɨОlw^j*%5uNJzKૺ#~b8ӹs5Uι 9"-T!4(<+})͐࢘PK(ߪ3Q%zA-S@0-?pn,v œE||x瞀-{P|o"53AS&kB؆)dnV.%
]6%\RcuG1c3l"V;\)rpu QX?39ӹ%v36wע{2
P7=xNbP"PW.c
0eYT:e`K-fkJ2\~5Ĭ1{TfnbS8+t&AJIfAKjdyJzINjׯGlT,oQoOAO!AB{G#m)@S"Rq\BdV9HAi?6M*7PYuR ({S/<]loV'6fIֹ%E?m