Ten Years HIV Free: An Interview with “The Berlin Patient,” Timothy Ray Brown

Michael M. Lederman, Earl Pike

Abstract


It was just about 10 years ago that Timothy Ray Brown was cured of HIV infection by receiving bone marrow stem cell transplantations from an HLA matched donor who also was homozygous for the CCR5 delta 32 mutation that renders immune cells resistant to infection by most HIV viruses. During an October 2017 visit to Cleveland to help launch a number of clinical trials targeting the Cure, Timothy sat down with Pathogens and Immunity editor Michael Lederman and community activist Earl Pike to talk about his experiences.


Keywords


HIV; immunization; antiretroviral

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References


1. Hutter G, Nowak D, Mossner M, Ganepola S, Mussig A, Allers K, Schneider T, Hofmann J, Kucherer C, Blau O, Blau IW, Hofmann WK, Thiel E. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692-8. PubMed PMID: 19213682. doi: 10.1056/NEJMoa0802905

2. Lederman MM, Cannon PM, Currier JS, June CH, Kiem H-P, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? Pathogens and Immunity. 2016;1(1):154-64. doi: 10.20411/pai.v1i1.133


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